A patient-specific lung cancer assembloid model with ... - Nature
WEBApr 20, 2024 — Here, we develop an innovative patient-specific lung cancer assembloid (LCA) model by using droplet microfluidic technology based on a microinjection strategy.
The lung microenvironment: an important regulator of tumour …
WEBDec 10, 2018 — In this Review, we summarize recent advances showing how the specialized lung TME supports both primary lung cancer and metastasis from extrapulmonary carcinoma and discuss how the...
Therapeutic Implications of Tumor Microenvironment in Lung Cancer ...
WEBJan 7, 2022 — In the last decade great efforts have been made to identify reliable predictive TME-based signatures for lung cancer immunotherapy. Currently, one of the most powerful prognostic tools in oncology is “immunoscore” (IS) based on the numbering of T lymphocytes within the tumor .
Harnessing TME depicted by histological images to improve cancer ...
WEBMay 1, 2024 — In the rapidly expanding healthcare data landscape, our study provides a powerful tool for TME analysis and cancer prognosis based on a large number of histological images from patient cohorts with cancer.
The updated landscape of tumor microenvironment and drug …
WEBAug 25, 2020 — Herein, we present an updated image of TME with emphasis on hypoxic niche, immune microenvironment, metabolism microenvironment, acidic niche, innervated niche, and mechanical...
WEBIMAGES OF LUNG CANCER. Brian Cone*, Thomas Jensen, Zihang Fang, Kevin de Haan, Serge Alexanian, Luis AV Carvalho, Yair Rivenson, Raymond Kozikowski. PictoLabs, Los Angeles, CA, USA. Background Lung cancer, the worldwide leading cause of can-cer-related deaths, is expected to account for over 127,000 deaths in the United States in 2023.
The metastasizing mechanisms of lung cancer: Recent advances …
WEBJun 1, 2021 — This paper focuses on the factors affecting lung cancer metastasis and connects with related molecular mechanisms of the lung cancer metastasis and mechanisms of lung cancer to specific organs, which mainly reviews the latest research progress of NSCLC metastasis.
Computational Staining of Pathology Images to Study the Tumor ...
WEBMay 15, 2020 — From these image-derived TME features, we developed a prognostic model for patients with lung adenocarcinoma and independently validated it in another lung adenocarcinoma patient cohort. The prognostic model predicts patient survival independent of other clinical variables in the validation cohort.
Deep learning-based six-type classifier for lung cancer and …
WEBMar 29, 2021 — We developed the first deep learning-based six-type classifier for histopathological WSI classification of lung adenocarcinoma, lung squamous cell carcinoma, small cell lung carcinoma, pulmonary tuberculosis, organizing pneumonia, and …
Targeting tumor microenvironment for non-small cell lung cancer ...
WEBMar 1, 2023 — In this review, we explore the heterogeneity of the TME in non-small cell lung cancer, summarize progress made in targeting the TME in preclinical and clinical studies, discuss the potential predictive value of the TME in immunotherapy, and highlight the promising effects of bispecific antibodies in the era of immunotherapy.