Direct injection into the dorsal root ganglion: Technical, …
WEBJul 7, 2011 — Injection of adeno-associated virus (AAV) vector conveying green fluorescent protein (GFP) transgene resulted in expression as soon as 1 day after injection into the DRG, including fibers in the spinal dorsal horn and columns.
Characterisation of GFAP-Expressing Glial Cells in the Dorsal Root ...
WEBOct 25, 2023 — Satellite glial cells (SGCs), enveloping primary sensory neurons' somas in the dorsal root ganglion (DRG), contribute to neuropathic pain upon nerve injury. Glial fibrillary acidic protein (GFAP) serves as an SGC activation marker, though its DRG satellite cell specificity is debated.
Effective gene expression in the rat dorsal root ganglia with a non ...
WEBOct 17, 2016 — Delivering gene constructs into the dorsal root ganglia (DRG) is a powerful but challenging therapeutic strategy for sensory disorders affecting the DRG and their peripheral processes.
Dorsal root ganglion macrophages contribute to both the …
WEBJan 14, 2020 — Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant expansion and proliferation of macrophages around injured sensory neurons in dorsal root ganglia (DRG).
Sensory satellite glial Gq-GPCR activation alleviates ... - Nature
WEBAug 25, 2020 — Resident GFAP + glia in dorsal root ganglia (DRG) known as satellite glial cells (SGCs) potentiate neuronal activity by releasing pro-inflammatory cytokines and neuroactive compounds. In this...
Tumour-associated macrophages and Schwann cells promote
WEBDec 22, 2023 — The DRG outgrowth index decreased in DRG treated with the GFAP inhibitor. Collectively, these results suggest that TAMs promote Schwann cell activation through a GFAP-dependent mechanism.
Glial fibrillary acidic protein promoter determines transgene ...
WEBThe present study evaluated whether in vivo satellite glial cell (SGC) transduction in the DRG can be enhanced by the SGC-specific GFAP promoter and by using shH10 and shH19, which are engineered capsid variants with Müller glia-prone transduction.
Satellite glia activation in dorsal root ganglion contributes to ...
WEBJul 1, 2020 — Glial fibrillary acidic protein (GFAP) was used as a marker of SGC activation. Unilateral C8VA resulted in mechanical allodynia, but not thermal hyperalgesia in bilateral paws.
Intimate Role for Adult Dorsal Root Ganglia Resident Cycling …
WEBAug 28, 2018 — We found rises in GFAP + cells in the axotomized DRG indicating activation and potential turnover of SGCs. Several large caliber neurons had remarkable focal expansion of activated SGCs surrounding them indicating repopulation of SGCs around injured neurons ( Fig. 1C, H ).
Characterisation of GFAP-Expressing Glial Cells in the Dorsal Root ...
WEBOct 25, 2023 — Satellite glial cells (SGCs), enveloping primary sensory neurons’ somas in the dorsal root ganglion (DRG), contribute to neuropathic pain upon nerve injury. Glial fibrillary acidic protein (GFAP) serves as an SGC activation marker, though its DRG satellite cell specificity is debated.